Mechanistic studies of the anticancer activity of an octahedral hexanuclear Pt(II) cage
Name
Hemann_Mechanistic studies.pdf
Size
791.07 KB
Format
Adobe PDF
Checksum (MD5)
47aaa3238b5dced2b5bc9d38b738ee4a
Author(s)
Zheng, Yaorong
Suntharalingam, Kogularamanan
Bruno, Peter Michael
Lin, Wei
Wang, Weixue
Hemann, Michael
Lippard, Stephen J.
Date Issued
March 2016
Journal
Inorganica Chimica Acta
Publisher
Elsevier
Citation
Zheng, Yao-Rong et al. “Mechanistic Studies of the Anticancer Activity of an Octahedral Hexanuclear Pt(II) Cage.” Inorganica Chimica Acta 452 (October 2016): 125–129 © 2016 Elsevier B.V.
Version
Author's final manuscript
Abstract
The cellular response evoked by a hexanuclear platinum complex, Pt6L4(1), is reported. Compound 1, a 3-nm octahedral cage formed by self-assembly of six Pt(II) centers and four 2,4,6-tris(4-pyridyl)-1,3,5-triazine ligands (L), exhibits promising in vitro potency against a panel of human cancer cell lines. Unlike classical platinum-based anticancer agents, 1 interacts with DNA in a non-covalent, intercalative manner and promotes DNA condensation. In cancer cells, 1 induces DNA damage, upregulates p53, its phosphorylated form phospho-p53 and its downstream effector, p21, as well as both apoptosis and senescence. Keywords: Self-assembly; Cage; Anticancer; DNA damage
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.ICA.2016.03.021
