Repressive Transcription
Name
Young_Repressive transcription.pdf
Size
189.21 KB
Format
Adobe PDF
Checksum (MD5)
6ced5ed291fd3c7f815377acdce62b78
Author(s)
Young, Richard A.
Guenther, Matthew
Date Issued
July 2010
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Guenther, M. G., and R. A. Young. “Repressive Transcription.” Science 329, no. 5988 (July 8, 2010): 150-151.
Version
Author's final manuscript
Abstract
How are active and repressed portions of the genome established and maintained during development? In vertebrates, about 2 m of DNA is packaged into chromatin in a manner that allows for active transcription of some loci and repression of others. Most chromatin regulators do not recognize specific DNA sequences, so how are they recruited to specific sites throughout the genome? For actively transcribed genes, transcription factors or the transcription initiation apparatus recruit regulators associated with active chromatin (1). For genes that are repressed, recent studies suggest a counterintuitive model: Transcription initiates the formation of repressive chromatin (2–9).
Description
2011 July 9 Author Manuscript
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1126/science.1193995
