Chemical Tools for Studying Directed Cell Migration
Name
Goguen-ACS CB Review Final.pdf
Size
1.13 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Goguen, Brenda N.
Imperiali, Barbara
Date Issued
October 2011
Journal
ACS Chemical Biology
Publisher
American Chemical Society (ACS)
Citation
Goguen, Brenda N., and Barbara Imperiali. “Chemical Tools for Studying Directed Cell Migration.” ACS Chemical Biology 6.11 (2011): 1164–1174.
Version
Author's final manuscript
Abstract
Cell migration is required for many physiological processes, including wound repair and embryogenesis, and relies on precisely orchestrated events that are regulated in a spatially and temporally controlled manner. Most traditional approaches for studying migration, such as genetic methods or the use of chemical inhibitors, do not offer insight into these important components of protein function. However, chemical tools, which respond on a more rapid time scale and in localized regions of the cell, are capable of providing more detailed, real-time information. This Review describes these recent approaches to investigate cell migration and focuses on proteins that are activated by light or small molecules, as well as fluorescent sensors of protein activity.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1021/cb200299k
