Measuring Instantaneous Frequency of Local Field Potential Oscillations using the Kalman Smoother
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Brown-Measuring Instantaneous Frequency.pdf
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1.9 MB
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Author(s)
Nguyen, David P.
Wilson, Matthew A.
Brown, Emery N.
Barbieri, Riccardo
Date Issued
August 2009
Journal
Journal of Neuroscience Methods
Publisher
Elsevier B.V.
Citation
Nguyen, David P. et al. “Measuring Instantaneous Frequency of Local Field Potential Oscillations Using the Kalman Smoother.” Journal of Neuroscience Methods 184.2 (2009): 365–374. Web.
Version
Author's final manuscript
Abstract
Rhythmic local field potentials (LFPs) arise from coordinated neural activity. Inference of neural function based on the properties of brain rhythms remains a challenging data analysis problem. Algorithms that characterize non-stationary rhythms with high temporal and spectral resolution may be useful for interpreting LFP activity on the timescales in which they are generated. We propose a Kalman smoother based dynamic autoregressive model for tracking the instantaneous frequency (iFreq) and frequency modulation (FM) of noisy and non-stationary sinusoids such as those found in LFP data. We verify the performance of our algorithm using simulated data with broad spectral content, and demonstrate its application using real data recorded from behavioral learning experiments. In analyses of ripple oscillations (100–250 Hz) recorded from the rodent hippocampus, our algorithm identified novel repetitive, short timescale frequency dynamics. Our results suggest that iFreq and FM may be useful measures for the quantification of small timescale LFP dynamics.
MIT Department
Whitaker College of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1016/j.jneumeth.2009.08.012
