Anterior thalamic circuits crucial for working memory
Name
pnas.2118712119.pdf
Description
Published version
Size
2.06 MB
Format
Adobe PDF
Checksum (MD5)
e39949e3c8b14bbe0e1c41ab6e6e569b
Author(s)
Roy, Dheeraj S
Zhang, Ying
Aida, Tomomi
Shen, Chenjie
Skaggs, Keith M
Hou, Yuanyuan
Fleishman, Morgan
Mosto, Olivia
Weninger, Alyssa
Feng, Guoping
Date Issued
2022
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
Proceedings of the National Academy of Sciences
Citation
Roy, Dheeraj S, Zhang, Ying, Aida, Tomomi, Shen, Chenjie, Skaggs, Keith M et al. 2022. "Anterior thalamic circuits crucial for working memory." Proceedings of the National Academy of Sciences of the United States of America, 119 (20).
Version
Final published version
Abstract
Significance
Anterior thalamus exhibits significant functional changes with increasing age. While it has been associated with cognitive functions, the specific circuitry relevant for working memory remains unknown. The significance of this study is threefold: First, the anteroventral subdivision of anterior thalamic nuclei is necessary for working memory maintenance; second, aged mice showed a decrease in the excitability of anteroventral thalamic neurons, which correlated with a working memory impairment; and third, activating anteroventral thalamic neurons in aged mice was sufficient to improve their working memory.
Anterior thalamus exhibits significant functional changes with increasing age. While it has been associated with cognitive functions, the specific circuitry relevant for working memory remains unknown. The significance of this study is threefold: First, the anteroventral subdivision of anterior thalamic nuclei is necessary for working memory maintenance; second, aged mice showed a decrease in the excitability of anteroventral thalamic neurons, which correlated with a working memory impairment; and third, activating anteroventral thalamic neurons in aged mice was sufficient to improve their working memory.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1073/PNAS.2118712119
