Messenger RNA modifications: Form, distribution, and function
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Gilbert_Messenger RNA.pdf
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742.32 KB
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Author(s)
Gilbert, Wendy
Bell, Tristan Andrew
Schaening, Cassandra
Date Issued
June 2016
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Gilbert, W. V., T. A. Bell, and C. Schaening. “Messenger RNA Modifications: Form, Distribution, and Function.” Science 352.6292 (2016): 1408–1412.
Version
Author's final manuscript
Abstract
RNA contains more than 100 distinct modifications that promote the functions of stable noncoding RNAs in translation and splicing. Recent technical advances have revealed widespread and sparse modification of messenger RNAs with N[superscript 6]-methyladenosine (m[superscript 6]A), 5-methylcytosine (m[superscript 5]C) and pseudouridine (Ψ). Here we discuss the rapidly evolving understanding of the location, regulation and function of these dynamic mRNA marks, collectively termed the epitranscriptome. We highlight differences among modifications and between species that could instruct ongoing efforts to understand how specific mRNAs target sites are selected and how their modification is
regulated. Diverse molecular consequences of individual m[superscript 6]A modifications are beginning to be revealed but the effects of m[superscript 5]C and Ψ remain largely unknown. Future work linking molecular effects to organismal phenotypes will broaden our understanding of mRNA modifications as cell and developmental regulators.
MIT Department
Massachusetts Institute of Technology. Computational and Systems Biology Program
Massachusetts Institute of Technology. Department of Biology
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1126/science.aad8711
