Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging
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Bawendi_Compact zwitterion.pdf
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1.75 MB
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Author(s)
Wei, He
Chen, Ou
Bawendi, Moungi G.
Bruns, Oliver Thomas
Date Issued
October 2012
Journal
Integrative Biology
Publisher
Royal Society of Chemistry, The
Citation
Wei, He, Oliver T. Bruns, Ou Chen, and Moungi G. Bawendi. “Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging.” Integrative Biology 5, no. 1 (2012): 108.
Version
Author's final manuscript
Abstract
We have recently developed compact and water-soluble zwitterionic dopamine sulfonate (ZDS) ligand coated superparamagnetic iron oxide nanoparticles (SPIONs) for use in various biomedical applications. The defining characteristics of ZDS-coated SPIONs are small hydrodynamic diameters, low non-specific interactions with fetal bovine serum, the opportunity for specific labeling, and stability with respect to time, pH, and salinity. We report here on the magnetic characterization of ZDS-coated SPIONs and their in vitro and in vivo performance relative to non-specific interactions with HeLa cells and in mice, respectively. ZDS-coated SPIONs retained the superparamagnetism and saturation magnetization (M[subscript s]) of as-synthesized hydrophobic SPIONs, with M[subscript s] = 74 emu g[superscript −1] [Fe]. Moreover, ZDS-coated SPIONs showed only small non-specific uptake into HeLa cancer cells in vitro and low non-specific binding to serum proteins in vivo in mice.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
http://dx.doi.org/10.1039/c2ib20142a
