The genomic basis of adaptive evolution in threespine sticklebacks
Name
Lander_The genomic basis.pdf
Size
3.56 MB
Format
Adobe PDF
Checksum (MD5)
1c246e829ab911e242cf352201af795c
Author(s)
Lander, Eric Steven
Date Issued
April 2012
Journal
Nature
Publisher
Nature Publishing Group
Citation
Jones, Felicity C. et al. “The Genomic Basis of Adaptive Evolution in Threespine Sticklebacks.” Nature 484.7392 (2012): 55–61. Web.
Version
Author's final manuscript
Abstract
Marine stickleback fish have colonized and adapted to thousands of streams and lakes formed since the last ice age, providing an exceptional opportunity to characterize genomic mechanisms underlying repeated ecological adaptation in nature. Here we develop a high-quality reference genome assembly for threespine sticklebacks. By sequencing the genomes of twenty additional individuals from a global set of marine and freshwater populations, we identify a genome-wide set of loci that are consistently associated with marine–freshwater divergence. Our results indicate that reuse of globally shared standing genetic variation, including chromosomal inversions, has an important role in repeated evolution of distinct marine and freshwater sticklebacks, and in the maintenance of divergent ecotypes during early stages of reproductive isolation. Both coding and regulatory changes occur in the set of loci underlying marine–freshwater evolution, but regulatory changes appear to predominate in this well known example of repeated adaptive evolution in nature.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1038/nature10944
