mTOR Signaling in Growth Control and Disease
Name
Laplante-2012-mTOR Signaling in Gr.pdf
Size
1.85 MB
Format
Adobe PDF
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Author(s)
Laplante, Mathieu
Sabatini, David M.
Sabatini, David
Date Issued
April 2012
Journal
Cell
Publisher
Elsevier
Citation
Laplante, Mathieu, and David M. Sabatini. “mTOR Signaling in Growth Control and Disease.” Cell 149, no. 2 (April 2012): 274–293. © 2012 Elsevier Inc.
Version
Final published version
Abstract
The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration. Here, we review recent advances in our understanding of the mTOR pathway and its role in health, disease, and aging. We further discuss pharmacological approaches to treat human pathologies linked to mTOR deregulation.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.cell.2012.03.017
