Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer
Name
Sabatini_Dietary and.pdf
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1.22 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Mihaylova, Maria M.
Sabatini, David M.
Yilmaz, Omer
Mihaylova, Maria M.
Sabatini, David
Date Issued
March 2014
Journal
Cell Stem Cell
Publisher
Elsevier
Citation
Mihaylova, Maria M., David M. Sabatini, and Ömer H. Yilmaz. “Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer.” Cell Stem Cell 14, no. 3 (March 2014): 292–305.
Version
Author's final manuscript
Abstract
Organismal diet has a profound impact on tissue homeostasis and health in mammals. Adult stem cells are a keystone of tissue homeostasis that alters tissue composition by balancing self-renewal and differentiation divisions. Because somatic stem cells may respond to shifts in organismal physiology to orchestrate tissue remodeling and some cancers are understood to arise from transformed stem cells, there is a likely possibility that organismal diet, stem cell function, and cancer initiation are interconnected. Here we will explore the emerging effects of diet on nutrient-sensing pathways active in mammalian tissue stem cells and their relevance to normal and cancerous growth.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.stem.2014.02.008
