Particulates from hydrophilic-coated guiding sheaths embolise to the brain
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Author(s)
Stanley, James R.L.
Tzafriri, Abraham R.
Regan, Kathryn
LaRochelle, Alan
Wong, Gee
Zani, Brett G.
Markham, Peter M.
Bailey, Lynn
Spognardi, Anna
Kopia, Gregory A.
Date Issued
March 2016
Journal
EuroIntervention
Publisher
Europa Organization
Citation
Stanley, James R. L., Abraham R. Tzafriri, Kathryn Regan, Alan LaRochelle, Gee Wong, Brett G. Zani, Peter M. Markham, Lynn Bailey, Anna Spognardi, Gregory A. Kopia, and Elazer R. Edelman. "Particulates from hydrophilic-coated guiding sheaths embolise to the brain." EuroIntervention 2016 March 20; 11(12): 1435–1441.
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Author's final manuscript
Abstract
Aims: We sought to evaluate the incidence of embolic material in porcine brains following vascular interventions using hydrophilic-coated sheaths. Methods and results: A new self-expanding stent and delivery system (SDS) was deployed through a hydrophilic-coated (Flexor® Ansel; Cook Medical, Bloomington, IN, USA) guiding sheath into the iliac and/or carotid arteries of 23 anaesthetised Yucatan mini swine. The animals were euthanised at three, 30, 90 and 180 days and their brains were removed for histological analysis. In an additional single control animal, the guiding sheath was advanced but no SDS was deployed. Advancement of the coated guiding sheath with or without the SDS was associated with frequent foreign material in the arterioles of the brain. The embolic material was amorphous, non-refractile, non-crystalline, non-birefringent and typically lightly basophilic with a slightly stippled appearance on haematoxylin and eosin (H&E) stain. Material was observed at all time points involving 54% of all study animals (i.e., test and control) and in vitro after incubation in 0.9% saline. Conclusions: The hydrophilic coating on a clinically used guiding sheath readily avulses and embolises to the brain during deployment in a porcine model. Further documentation of this effect and monitoring in clinical scenarios are warranted.
Description
available in PMC 2016 March 23
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
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DOI of Published Version
https://doi.org/10.4244/EIJY15M03_02
