The redox requirements of proliferating mammalian cells
Name
1-s2.0-S0021925820369490-main.pdf
Description
Published version
Size
870.29 KB
Format
Adobe PDF
Checksum (MD5)
cc7458e95deac7007773c6f4f693f24c
Author(s)
Hosios, Aaron M
Vander Heiden, Matthew G
Date Issued
2018
Journal
Journal of Biological Chemistry
Publisher
Elsevier BV
Version
Final published version
Abstract
Cell growth and division require nutrients, and proliferating cells use a variety of sources to acquire the amino acids, lipids, and nucleotides that support macromolecule synthesis. Lipids are more reduced than other nutrients, whereas nucleotides and amino acids are typically more oxidized. Cells must therefore generate reducing and oxidizing (redox) equivalents to convert consumed nutrients into biosynthetic precursors. To that end, redox cofactor metabolism plays a central role in meeting cellular redox requirements. In this Minireview, we highlight the biosynthetic pathways that involve redox reactions and discuss their integration with metabolism in proliferating mammalian cells.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1074/JBC.TM117.000239
