Fingerprint and high-wavenumber Raman spectroscopy in a human-swine coronary xenograft in vivo
Name
Chau-2008-Fingerprint and high.pdf
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Author(s)
Chau, Alexandra H.
Motz, Jason T.
Gardecki, Joseph A.
Waxman, Sergio
Bouma, Brett E.
Tearney, Guillermo J.
Date Issued
January 2008
Journal
Journal of Biomedical Optics
Publisher
SPIE - International Society for Optical Engineering
Citation
Chau, Alexandra H. et al. “Fingerprint and High-wavenumber Raman Spectroscopy in a Human-swine Coronary Xenograft in Vivo.” Journal of Biomedical Optics 13.4 (2008): 040501. Web. 15 Feb. 2012. © 2011 SPIE - International Society for Optical Engineering
Version
Final published version
Abstract
Intracoronary Raman spectroscopy could open new avenues for the study and management of coronary artery disease due to its potential to measure the chemical and molecular composition of coronary atherosclerotic lesions. We have fabricated and tested a 1.5-mm-diameter (4.5 Fr) Raman catheter capable of collecting Raman spectra in both the fingerprint (400–1800 cm[superscript −1]) and high-wavenumber (2400–3800 cm[superscript −1]) regions. Spectra were acquired in vivo, using a human-swine xenograft model, in which diseased human coronary arteries are grafted onto a living swine heart, replicating the disease and dynamic environment of the human circulatory system, including pulsatile flow and motion. Results show that distinct spectral differences, corresponding to the morphology and chemical composition of the artery wall, can be identified by intracoronary Raman spectroscopy in vivo.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1117/1.2960015
