Cortical Folding Patterns and Predicting Cytoarchitecture
Name
Fischl-2007-Cortical Folding Patterns and Predicting Cytoarchitecture.pdf
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837.48 KB
Format
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Checksum (MD5)
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Author(s)
Rajendran, Niranjini
Busa, Evelina
Augustinack, Jean
Mohlberg, Hartmut
Amunts, Katrin
Zilles, Karl
Fischl, Bruce
Hinds, Oliver
Yeo, B. T. Thomas
Date Issued
December 2007
Journal
Cerebral Cortex
Publisher
Oxford University Press (OUP)
Citation
Fischl, B. et al. “Cortical Folding Patterns and Predicting Cytoarchitecture.” Cerebral Cortex 18.8 (2007): 1973–1980. Web. 25 May 2012.
Version
Final published version
Abstract
The human cerebral cortex is made up of a mosaic of structural areas, frequently referred to as Brodmann areas (BAs). Despite the widespread use of cortical folding patterns to perform ad hoc estimations of the locations of the BAs, little is understood regarding 1) how variable the position of a given BA is with respect to the folds, 2) whether the location of some BAs is more variable than others, and 3) whether the variability is related to the level of a BA in a putative cortical hierarchy. We use whole-brain histology of 10 postmortem human brains and surface-based analysis to test how well the folds predict the locations of the BAs. We show that higher order cortical areas exhibit more variability than primary and secondary areas and that the folds are much better predictors of the BAs than had been previously thought. These results further highlight the significance of cortical folding patterns and suggest a common mechanism for the development of the folds and the cytoarchitectonic fields.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
McGovern Institute for Brain Research at MIT
Terms of Use
Creative Commons Attribution Non-Commercial
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DOI of Published Version
https://doi.org/10.1093/cercor/bhm225
