PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of C. elegans
Name
elife-36547-v1.pdf
Size
1.19 MB
Format
Adobe PDF
Checksum (MD5)
1872b0dd5ec162e7c5fedd0a5894e028
Author(s)
Hilbert, Zoe Alyse
Kim, Dennis H.
Date Issued
July 2018
Journal
eLife
Publisher
eLife Sciences Publications, Ltd
Citation
Hilbert, Zoë A and Dennis H Kim. “PDF-1 Neuropeptide Signaling Regulates Sexually Dimorphic Gene Expression in Shared Sensory Neurons of C. Elegans.” eLife 7 (July 2018): e36547 © 2018 The Authors
Version
Final published version
Abstract
Sexually dimorphic behaviors are a feature common to species across the animal kingdom, however how such behaviors are generated from mostly sex-shared nervous systems is not well understood. Building on our previous work which described the sexually dimorphic expression of a neuroendocrine ligand, DAF-7, and its role in behavioral decision-making in C. elegans (Hilbert and Kim, 2017), we show here that sex-specific expression of daf-7 is regulated by another neuroendocrine ligand, Pigment Dispersing Factor (PDF-1), which has previously been implicated in regulating male-specific behavior (Barrios et al., 2012). Our analysis revealed that PDF-1 signaling acts sex- and cell-specifically in the ASJ neurons to regulate the expression of daf-7, and we show that differences in PDFR-1 receptor activity account for the sex-specific effects of this pathway. Our data suggest that modulation of the sex-shared nervous system by a cascade of neuroendocrine signals can shape sexually dimorphic behaviors.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.7554/eLife.36547
