K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair
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1-s2.0-S2211124720309815-main.pdf
Description
Published version
Size
3.63 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Xiong, Aoli
Prakash, Prem
Gao, Xiaohong
Chew, Marvin
Tay, Jun Jie Ian
Woodrow, Charles J.
Engelward, Bevin P
Han, Jongyoon
Preiser, Peter Rainer
Date Issued
August 2020
Journal
Cell Reports
Publisher
Elsevier BV
Citation
Xiong, Aoli et al. "K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair." Cell Reports 32, 5 (August 2020): 107996 © 2020 The Author(s)
Version
Final published version
Abstract
Southeast Asia (SEA) has been the breeding ground for malaria drug resistance, including resistance to artemisinin, the first-line anti-malarial drug. In this study, Xiong et al. find a relationship between DNA damage repair and artemisinin resistance in SEA, leading to insights on the establishment and spread of current artemisinin resistance.
MIT Department
Singapore-MIT Alliance in Research and Technology (SMART)
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.1016/j.celrep.2020.107996
