A General Method for Suzuki–Miyaura Coupling Reactions Using Lithium Triisopropyl Borates
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Buchwald_A general method.pdf
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Author(s)
Buchwald, Stephen Leffler
Oberli, Matthias
Date Issued
August 2012
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Oberli, Matthias A., and Stephen L. Buchwald. “A General Method for Suzuki–Miyaura Coupling Reactions Using Lithium Triisopropyl Borates.” Organic Letters 14, no. 17 (September 7, 2012): 4606-4609.
Version
Author's final manuscript
Abstract
Conditions for the Suzuki–Miyaura coupling of lithium triisopropyl borates are reported, as well as a procedure for a one-pot lithiation, borylation, and subsequent Suzuki–Miyaura coupling of various heterocycles with aryl halides. These borate species are much more stable toward protodeboronation than the corresponding boronic acids and can conveniently be stored on benchtop at room temperature.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ol302063g
