Allocation of resources among multiple daughter cells
Name
jcb_202504177.pdf
Description
Published version
Size
9.38 MB
Format
Adobe PDF
Checksum (MD5)
5989c3a650db4d44bd4b62468f14fef6
Author(s)
Wirshing, Alison CE
Alonso-Matilla, Roberto
Yan, Michelle
Khalid, Samra
Colarusso, Analeigha V
Odde, David
Lew, Daniel J
Date Issued
November 3, 2025
Journal
Journal of Cell Biology
Publisher
Rockefeller University Press
Citation
Alison C.E. Wirshing, Roberto Alonso-Matilla, Michelle Yan, Samra Khalid, Analeigha V. Colarusso, David Odde, Daniel J. Lew; Allocation of resources among multiple daughter cells. J Cell Biol 3 November 2025; 224 (11): e202504177.
Version
Final published version
Abstract
Cell division commonly produces two daughter cells, but there are many exceptions where large cells produce multiple daughters. Multiple fission of some green algae and bacteria; cellularization during embryogenesis of plants and insects; and growth of Ichthyosporeans, Chytrids, and Apicomplexans all provide variations on this theme. In some yeast species, a large multinucleate mother cell grows multiple buds (daughters) simultaneously. Here, we address how mothers partition growth equally among their buds in the multi-budding yeast Aureobasidium pullulans. Bud growth is directed by actin cable networks that appear to be optimized for even partitioning despite complex cell geometries. Even partitioning does not rely on compensatory mechanisms to adjust bud volumes but rather stems directly from effective equalization of polarity sites. These results reveal how conserved cell polarity and cytoskeletal networks are adapted to build complex morphologies in fungi.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1083/jcb.202504177
