Development of oil-based gels as versatile drug delivery systems for pediatric applications
Name
sciadv.abm8478.pdf
Description
Published version
Size
7.21 MB
Format
Adobe PDF
Checksum (MD5)
1ce8e5946123d4bcfd3e511cf638b5c8
Author(s)
Kirtane, Ameya R.
Karavasili, Christina
Wahane, Aniket
Freitas, Dylan
Booz, Katelyn
Le, Dao Thi Hong
Hua, Tiffany
Scala, Stephen
Lopes, Aaron
Hess, Kaitlyn
Date Issued
May 27, 2022
Journal
Science Advances
Publisher
American Association for the Advancement of Science
Citation
Ameya R. Kirtane et al. ,Development of oil-based gels as versatile drug delivery systems for pediatric applications.Sci. Adv.8,eabm8478(2022).
Version
Final published version
Abstract
Administering medicines to 0- to 5-year-old children in a resource-limited environment requires dosage forms that circumvent swallowing solids, avoid on-field reconstitution, and are thermostable, cheap, versatile, and taste masking. We present a strategy that stands to solve this multifaceted problem. As many drugs lack adequate water solubility, our formulations used oils, whose textures could be modified with gelling agents to form “oleogels.” In a clinical study, we showed that the oleogels can be formulated to be as fluid as thickened beverages and as stiff as yogurt puddings. In swine, oleogels could deliver four drugs ranging three orders of magnitude in their water solubilities and two orders of magnitude in their partition coefficients. Oleogels could be stabilized at 40°C for prolonged durations and used without redispersion. Last, we developed a macrofluidic system enabling fixed and metered dosing. We anticipate that this platform could be adopted for pediatric dosing, palliative care, and gastrointestinal disease applications.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Division of Comparative Medicine
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1126/sciadv.abm8478
