Biomolecular Condensates and Cancer
Name
CANCER-CELL-D-20-01264_R1.pdf
Description
Accepted version
Size
12.12 MB
Format
Adobe PDF
Checksum (MD5)
d17a28f68aec52700d6a40eb0f9620ab
Author(s)
Boija, Ann
Klein, Isaac A.
Young, Richard A.
Date Issued
February 2021
Journal
Cancer Cell
Publisher
Elsevier BV
Citation
Boija, Ann et al. "Biomolecular Condensates and Cancer." Cancer Cell 39, 2 (February 2021): 174-192. © 2020 Elsevier Inc
Version
Author's final manuscript
Abstract
Malignant transformation is characterized by dysregulation of diverse cellular processes that have been the subject of detailed genetic, biochemical, and structural studies, but only recently has evidence emerged that many of these processes occur in the context of biomolecular condensates. Condensates are membrane-less bodies, often formed by liquid-liquid phase separation, that compartmentalize protein and RNA molecules with related functions. New insights from condensate studies portend a profound transformation in our understanding of cellular dysregulation in cancer. Here we summarize key features of biomolecular condensates, note where they have been implicated—or will likely be implicated—in oncogenesis, describe evidence that the pharmacodynamics of cancer therapeutics can be greatly influenced by condensates, and discuss some of the questions that must be addressed to further advance our understanding and treatment of cancer.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.ccell.2020.12.003
