Multimodality Imaging Atlas of Coronary Atherosclerosis
Name
Donnelly-2010-Multimodality Imagin.pdf
Size
1.98 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Donnelly, Patrick
Maurovich-Horvat, Pal
Vorpahl, Marc
Nakano, Masataka
Kaple, Ryan K.
Warger, William
Tanaka, Atsushi
Tearney, Guillermo
Virmani, Renu
Hoffmann, Udo
Date Issued
August 2010
Journal
JACC Cardiovascular Imaging
Publisher
Elsevier
Citation
Donnelly, Patrick, Pál Maurovich-Horvat, Marc Vorpahl, Masataka Nakano, Ryan K. Kaple, William Warger, Atsushi Tanaka, Guillermo Tearney, Renu Virmani, and Udo Hoffmann. “Multimodality Imaging Atlas of Coronary Atherosclerosis.” JACC: Cardiovascular Imaging 3, no. 8 (August 2010): 876–880. © 2010 American College of Cardiology Foundation
Version
Final published version
Abstract
NEW HIGH-RESOLUTION IMAGING TECHNOLOGIES HAVE ENHANCED OUR UNDERSTANDING OF THE CORONARY atherosclerotic disease process, and this atlas provides a multimodality pictorial review of the development of histologically verified coronary atherosclerosis. A modified American Heart Association classification scheme system based on morphological plaque features and the propensity of plaque for thrombosis or cause of sudden cardiac death has recently been proposed. This classification scheme incorporates 5 categories of coronary atherosclerotic lesions (Table 1) (1 and 2). These categories include nonatherosclerotic lesions (intimal thickening and intimal xanthoma) and progressive atherosclerotic lesions (pathological intimal thickening, fibroatheroma, thin fibrous cap atheroma, rupture, erosion, calcified nodule, and fibrocalcific plaque). The description of these categories is based on the accretion of lipid in relationship to fibrous cap formation, lipid pool transition into necrotic core, the thinning or thickening of fibrous cap, and presence of thrombosis. Furthermore, plaque characteristics such as angiogenesis, intraplaque hemorrhage, inflammation, calcification, cell death, and proteolysis are presented as descriptive terms along with features like culprit lesion associated with thrombus. This multimodality imaging atlas of ex vivo human hearts illustrates this morphological classification through computed tomography (CT), intravascular ultrasound (IVUS), optical frequency domain imaging (OFDI) and corresponding histological characteristics.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.jcmg.2010.06.006
