Induced Pluripotent Stem Cells Meet Genome Editing
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nihms783629.pdf
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562.21 KB
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Adobe PDF
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368f1d6438686e330ae67ccc206d686d
Author(s)
Hockemeyer, Dirk
Jaenisch, Rudolf
Date Issued
May 2016
Journal
Cell Stem Cell
Publisher
Elsevier
Citation
Hockemeyer, Dirk, and Rudolf Jaenisch. “Induced Pluripotent Stem Cells Meet Genome Editing.” Cell Stem Cell 18, 5 (May 2016): 573–586 © 2016 Elsevier Inc
Version
Author's final manuscript
Abstract
It is extremely rare for a single experiment to be so impactful and timely that it shapes and forecasts the experiments of the next decade. Here, we review how two such experiments - the generation of human induced pluripotent stem cells (iPSCs) and the development of CRISPR/Cas9 technology - have fundamentally reshaped our approach to biomedical research, stem cell biology, and human genetics. We will also highlight the previous knowledge that iPSC and CRISPR/Cas9 technologies were built on as this groundwork demonstrated the need for solutions and the benefits that these technologies provided and set the stage for their success.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.STEM.2016.04.013
