MicroRNA networks regulate development of brown adipocytes
Name
Lodish_MicroRNA networks.pdf
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1.93 MB
Format
Adobe PDF
Checksum (MD5)
904915b863712b3d640ae872dc065842
Author(s)
Trajkovski, Mirko
Lodish, Harvey F
Date Issued
September 2013
Journal
Trends in Endocrinology & Metabolism
Citation
Trajkovski, Mirko, and Harvey Lodish. “MicroRNA Networks Regulate Development of Brown Adipocytes.” Trends in Endocrinology & Metabolism 24.9 (2013): 442–450.
Version
Author's final manuscript
Abstract
Brown adipose tissue (BAT) is specialized for heat generation and energy expenditure as a defense against cold and obesity; in both humans and mice increased amounts of BAT are associated with a lean phenotype and resistance to development of the metabolic syndrome and its complications. Here we summarize recent research showing that several BAT-expressed microRNAs (miRNAs) play important roles in regulating differentiation and metabolism of brown and beige adipocytes; we discuss the key mRNA targets downregulated by these miRNAs and show how these miRNAs affect directly or indirectly transcription factors important for BAT development. We suggest that these miRNAs could be part of novel therapeutics to increase BAT in humans.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.tem.2013.05.002
