Recommendations for Standardized Description of and Nomenclature Concerning Oxidatively Damaged Nucleobases in DNA
Name
Cooke et al CRT Position Paper DEDON 2010 10-16.pdf
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179.6 KB
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Author(s)
Cooke, Marcus S.
Loft, Steffen
Olinski, Ryszard
Evans, Mark D.
Bialkowski, Karol
Wagner, J. Richard
Dedon, Peter C.
Moller, Peter
Greenberg, Marc M.
Cadet, Jean
Date Issued
April 2010
Journal
Chemical Research in Toxicology
Publisher
American Chemical Society
Citation
Cooke, Marcus S. et al. “Recommendations for Standardized Description of and Nomenclature Concerning Oxidatively Damaged Nucleobases in DNA.” Chemical Research in Toxicology 23.4 (2010): 705-707.
Version
Author's final manuscript
Abstract
Despite being a relatively young field, the study of oxidative stress has attracted huge interest. With the advent of simple and relatively inexpensive assays (sometimes from commercial suppliers), a growing number of groups have been able to assess oxidatively generated DNA damage in mammalian cells. While this is good for raising the profile of the field of oxidative stress research, it has led to an increasing number of issues when the work is written up for publication and included in grant applications. In particular, it is evident to experts in the field, editors and referees alike, that there is often uncertainty concerning what is appropriate and accurate terminology, when describing studies concerning the effects of oxidatively generated DNA damage. For this reason, we wish to raise a number of points for discussion, incorporating our recommendations on this subject. The aim is to support those embarking on studies involving oxidatively generated damage to DNA nucleobases and to produce greater uniformity across the field. We do not wish to be dogmatic, but to present a well-argued rationale for our recommendations.
Description
Letters to the Editor
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1021/tx1000706
