Long-term proton pump inhibitor administration, H pylori and gastric cancer: lessons from the gerbil
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Fox-2011-Long-term proton pump inhibitor.pdf
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Author(s)
Fox, James G.
Kuipers, Ernst J.
Date Issued
May 2011
Journal
Gut
Publisher
British Medical Association
Citation
Fox, James G., and Ernst J. Kuipers. “Long-term Proton Pump Inhibitor Administration, H Pylori and Gastric Cancer: Lessons from the Gerbil.” Gut 60.5 (2011) : 567 -568.© 2011 BMJ Publishing Group Ltd.
Version
Final published version
Abstract
The association between chronic active gastritis and pre-neoplastic conditions as well as invasive cancer of the stomach was established several decades ago. The risk of progression depended on the severity and distribution of gastritis, with cancer, in particular, occurring in subjects with pan-gastritis. Subsequently, Helicobacter pylori was recognised as the primary cause of chronic active gastritis, and it was demonstrated that the pattern of gastritis corresponded with the colonisation pattern of H pylori. We and others then showed both in animals and in humans that this pattern of colonisation and associated gastritis primarily depended on the level of acid output. 1 2 Although this hypothesis was widely accepted, it led to intense debate when dealing with the safety of long-term treatment with profound acid suppressors. An elegant, long-awaited study from Japan published in this issue of Gut ( see page 624) provides compelling evidence that the pattern of H pylori colonisation depends on acid output and that this influences the long-term progression to neoplasia. The current study was based on experiments
in gerbils, one of the well-established
animal models for the study gastric
disease induced by Helicobacter spp.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Division of Comparative Medicine
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1136/gut.2010.229286
