Scalable Gastric Resident Systems for Veterinary Application
Name
s41598-018-30212-3.pdf
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1.43 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Hayward, Alison M
Bensel, Taylor A
Mazdiyasni, Hormoz
Rogner, Jaimie L
Kirtane, Ameya
Lee, Young-Ah
Hua, Tiffany P
Bajpayee, Ambika Goel
Collins, Joy E
McDonnell, Shane
Date Issued
August 2018
Journal
Scientific Reports
Publisher
Nature Publishing Group
Citation
Hayward, Alison, Taylor Bensel, Hormoz Mazdiyasni, Jaimie Rogner, Ameya R. Kirtane, Young-Ah Lucy Lee, Tiffany Hua, et al. “Scalable Gastric Resident Systems for Veterinary Application.” Scientific Reports 8, no. 1 (August 7, 2018).
Version
Final published version
Abstract
Gastric resident dosage forms have been used successfully in farm animals for the delivery of a variety of drugs helping address the challenge of extended dosing. Despite these advances, there remains a significant challenge across the range of species with large variation in body size. To address this, we investigate a scalable gastric resident platform capable of prolonged retention. We investigate prototypes in dimensions consistent with administration and retention in the stomachs of two species (rabbit and pig). We investigate sustained gastric retention of our scalable dosage form platform, and in pigs show the capacity to modulate drug release kinetics of a model drug in veterinary practice, meloxicam, with our dosage form. The ability to achieve gastric residence and thereby enable sustained drug levels across different species may have a significant impact in the welfare of animals in both research, agricultural, zoological, and clinical practice settings.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Division of Comparative Medicine
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International License
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DOI of Published Version
https://doi.org/10.1038/s41598-018-30212-3
