A mechanical approach for smooth surface fitting to delineate vessel walls in optical coherence tomography images
Name
nihms-999238.pdf
Description
Accepted version
Size
4.05 MB
Format
Adobe PDF
Checksum (MD5)
e259ecc4327165b58dc4973fe186c15e
Author(s)
Olender, Max
Athanasiou, Lambros S.
Hernández, José M. de la Torre
Ben-Assa, Eyal
Rikhtegar Nezami, Farhad
Edelman, Elazer R
Date Issued
June 2019
Journal
IEEE Transactions on Medical Imaging
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Citation
Olender, Max L. et al. "A mechanical approach for smooth surface fitting to delineate vessel walls in optical coherence tomography images." IEEE Transactions on Medical Imaging 38, 6 (June 2019): 1384-1397 ©2019 Author(s)
Version
Author's final manuscript
Abstract
Automated analysis of vascular imaging techniques is limited by the inability to precisely determine arterial borders. Intravascular optical coherence tomography (OCT) offers unprecedented detail of artery wall structure and composition, but does not provide consistent visibility of the outer border of the vessel due to the limited penetration depth. Existing interpolation and surface fitting methods prove insufficient to accurately fill the gaps between the irregularly spaced and sometimes unreliably identified visible segments of the vessel outer border. This paper describes an intuitive, efficient, and flexible new method of 3D surface fitting and smoothing suitable for this task. An anisotropic linear-elastic mesh is fit to irregularly spaced and uncertain data points corresponding to visible segments of vessel borders, enabling the fully automated delineation of the entire inner and outer borders of diseased vessels in OCT images for the first time. In a clinical dataset, the proposed smooth surface fitting approach had great agreement when compared with human annotations: areas differed by just 11 ± 11% (0.93 ± 0.84 mm2), with a coefficient of determination of 0.89. Overlapping and non-overlapping area ratios were 0.91 and 0.18, respectively, with a sensitivity of 90.8 and specificity of 99.0. This spring mesh method of contour fitting significantly outperformed all alternative surface fitting and interpolation approaches tested. The application of this promising proposed method is expected to enhance clinical intervention and translational research using OCT.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1109/TMI.2018.2884142
