The 4D Nucleome Data Portal as a resource for searching and visualizing curated nucleomics data
Name
s41467-022-29697-4.pdf
Description
Published version
Size
2.16 MB
Format
Adobe PDF
Checksum (MD5)
bdb2fd9ff5bf8e0a6e77b30e2fc62753
Author(s)
Reiff, Sarah B
Schroeder, Andrew J
Kırlı, Koray
Cosolo, Andrea
Bakker, Clara
Mercado, Luisa
Lee, Soohyun
Veit, Alexander D
Balashov, Alexander K
Vitzthum, Carl
Date Issued
2022
Journal
Nature Communications
Publisher
Springer Science and Business Media LLC
Citation
Reiff, Sarah B, Schroeder, Andrew J, Kırlı, Koray, Cosolo, Andrea, Bakker, Clara et al. 2022. "The 4D Nucleome Data Portal as a resource for searching and visualizing curated nucleomics data." Nature Communications, 13 (1).
Version
Final published version
Abstract
AbstractThe 4D Nucleome (4DN) Network aims to elucidate the complex structure and organization of chromosomes in the nucleus and the impact of their disruption in disease biology. We present the 4DN Data Portal (https://data.4dnucleome.org/), a repository for datasets generated in the 4DN network and relevant external datasets. Datasets were generated with a wide range of experiments, including chromosome conformation capture assays such as Hi-C and other innovative sequencing and microscopy-based assays probing chromosome architecture. All together, the 4DN data portal hosts more than 1800 experiment sets and 36000 files. Results of sequencing-based assays from different laboratories are uniformly processed and quality-controlled. The portal interface allows easy browsing, filtering, and bulk downloads, and the integrated HiGlass genome browser allows interactive visualization and comparison of multiple datasets. The 4DN data portal represents a primary resource for chromosome contact and other nuclear architecture data for the scientific community.
MIT Department
Harvard-MIT Program in Health Sciences and Technology
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/S41467-022-29697-4
