Nanotechnology: emerging tools for biology and medicine
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Bhatia_Nanotechnology.pdf
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1.22 MB
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Adobe PDF
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f38cd88288483326d7d70fde1deb546b
Author(s)
Wong, Ian Y.
Toner, Mehmet
Bhatia, Sangeeta N
Date Issued
November 2013
Journal
Genes & Development
Publisher
Cold Spring Harbor Laboratory Press
Citation
Wong, I. Y., S. N. Bhatia, and M. Toner. “Nanotechnology: Emerging Tools for Biology and Medicine.” Genes & Development 27, no. 22 (November 15, 2013): 2397–2408.
Version
Final published version
Abstract
Historically, biomedical research has been based on two paradigms. First, measurements of biological behaviors have been based on bulk assays that average over large populations. Second, these behaviors have then been crudely perturbed by systemic administration of therapeutic treatments. Nanotechnology has the potential to transform these paradigms by enabling exquisite structures comparable in size with biomolecules as well as unprecedented chemical and physical functionality at small length scales. Here, we review nanotechnology-based approaches for precisely measuring and perturbing living systems. Remarkably, nanotechnology can be used to characterize single molecules or cells at extraordinarily high throughput and deliver therapeutic payloads to specific locations as well as exhibit dynamic biomimetic behavior. These advances enable multimodal interfaces that may yield unexpected insights into systems biology as well as new therapeutic strategies for personalized medicine
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution- NonCommercial-Share Alike 3.0 Unported licence.
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DOI of Published Version
https://doi.org/10.1101/gad.226837.113
