Development and optimization of high-throughput zebrafish screening platform
Name
710365719-MIT.pdf
Description
Full printable version
Size
7.45 MB
Format
Adobe PDF
Checksum (MD5)
67ab2f8811b243942efedf3911b41a2c
Author(s)
Koo, Bryan Kyo
Advisor(s)
Mehmet Fatih Yanik.
Alternative Title
Development and optimization of high-throughput vertebrae screening platform
Date Issued
2010
Publisher
Massachusetts Institute of Technology
Abstract
The high-throughput zebrafish screening platform is a revolutionary tool that enables subcellular precision in vivo whole animal screening of Danio Rerio. It can perform laser surgery and/or imaging in less than twenty seconds per fish. This is a two orders of magnitude improvement from the existing manual method, which takes 10 to 15 minutes per fish. The platform also has the ability to rotate the fish in any angle for imaging or laser surgery. There has never been a platform that could align and position a zebrafish consistently and efficiently in such manner before. This crucial functionality was realized through a design in which zebrafish was screened in a capillary tube.
Description
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 67-68).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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