MicroRNA delivery through nanoparticles
Name
1-s2.0-S0168365919305796-main.pdf
Description
Published version
Size
8.55 MB
Format
Adobe PDF
Checksum (MD5)
73559368c9694da3ab4eb83e54cedfdc
Author(s)
Lee, Sharon Wei Ling
Paoletti, Camilla
Campisi, Marco
Osaki, Tatsuya
Adriani, Giulia
Kamm, Roger Dale
Mattu, Clara
Chiono, Valeria
Date Issued
November 2019
Journal
Journal of Controlled Release
Publisher
Elsevier BV
Citation
Lee, Sharon Wei Ling et al. "MicroRNA delivery through nanoparticles." Journal of Controlled Release 313 (November 2019): 80-95 © 2019 The Authors
Version
Final published version
Abstract
MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to their central role in the etiology of major diseases. On the other hand, nanoparticle carriers offer unprecedented opportunities for cell specific controlled delivery of miRNAs for therapeutic purposes. This review critically discusses the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and neurodegenerative disorders and for tissue regeneration. A fresh perspective is presented on the design and characterization of nanocarriers to accelerate translation from basic research to clinical application of miRNA-nanoparticles. Main challenges in the engineering of miRNA-loaded nanoparticles are discussed, and key application examples are highlighted to underline their therapeutic potential for effective and personalized medicine.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.jconrel.2019.10.007
