The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery during Development
Name
Wang-2011-The Msx1 Homeoprotei.pdf
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Author(s)
Wang, Jingqiang
Kumar, Roshan M.
Biggs, Vanessa J.
Lee, Hansol
Chen, Yun
Kagey, Michael H.
Young, Richard A.
Abate-Shen, Cory
Date Issued
August 2011
Journal
Developmental Cell
Publisher
Elsevier
Citation
Wang, Jingqiang, Roshan M. Kumar, Vanessa J. Biggs, Hansol Lee, Yun Chen, Michael H. Kagey, Richard A. Young, and Cory Abate-Shen. “The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery During Development.” Developmental Cell 21, no. 3 (September 2011): 575–588. © 2011 Elsevier Inc.
Version
Final published version
Abstract
Control of gene expression during development requires the concerted action of sequence-specific transcriptional regulators and epigenetic modifiers, which are spatially coordinated within the nucleus through mechanisms that are poorly understood. Here we show that transcriptional repression by the Msx1 homeoprotein in myoblast cells requires the recruitment of Polycomb to target genes located at the nuclear periphery. Target genes repressed by Msx1 display an Msx1-dependent enrichment of Polycomb-directed trimethylation of lysine 27 on histone H3 (H3K27me3). Association of Msx1 with the Polycomb complex is required for repression and regulation of myoblast differentiation. Furthermore, Msx1 promotes a dynamic spatial redistribution of the H3K27me3 repressive mark to the nuclear periphery in myoblast cells and the developing limb in vivo. Our findings illustrate a hitherto unappreciated spatial coordination of transcription factors with the Polycomb complex for appropriate regulation of gene expression programs during development.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.devcel.2011.07.003
