7.88J / 7.24J / 5.48J / 10.543J Protein Folding Problem, Fall 2007
Name
7-88j-fall-2007/contents/index.htm
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33.14 KB
Format
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Checksum (MD5)
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Author(s)
King, Jonathan
Alternative Title
Protein Folding Problem
Date Issued
December 2007
Abstract
This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.
Subjects
260404
Developmental Biology and Embryology
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
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