Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces
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MEBCS025.pdf
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433.6 KB
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Author(s)
Seong, Jiehyun
Lee, Seok-Won
Jun, Shinae
Choi, Hyun-Goo
Laibinis, Paul E.
Date Issued
January 2003
Series/Report no.
Molecular Engineering of Biological and Chemical Systems (MEBCS);
Abstract
We have investigated a series of molecular and polymeric approaches for generating adherent thin films that impart anti-fouling characteristics to oxide surfaces. These films incorporate oligo- or poly(ethylene glycol) moieties that are expressed in high density in the near-surface region. In our molecular approach, oligo(ethylene glycol)-terminated n-alkyl-trichlorosilanes, RO(CH₂CH₂O)₃(CH₂)₁₁SiCl₃, have been designed so to spontaneously adsorb onto oxide surfaces and produce densely packed films. Another strategy uses a surface initiated polymerization to generate reactive anchored polymer chains that are then chemically modified to incorporate oligo(ethylene glycol) units. Lastly, a comb copolymer comprising a poly(acrylic acid) backbone and different grafting ratios of a linear poly(ethylene oxide-r-propylene oxide) chain has been prepared that adsorbs onto surfaces and forms a poly(ethylene glycol)-exposing film in single step. These surface coatings provide varying levels of protein and cellular resistance that can be related to molecular-scale elements of their surface structure.
Subjects
polymer coatings
protein adsorption
surface modification
thin films
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