DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy
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Xiao_2012-DNA self-assembly.pdf
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Author(s)
Xiao, Zeyu
Ji, Changwei
Shi, Jinjun
Frieder, Jillian
Wu, Jun
Farokhzad, Omid C.
Shi, JinJun
Pridgen, Eric M.
Date Issued
October 2012
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Xiao, Zeyu, Changwei Ji, Jinjun Shi, Eric M. Pridgen, Jillian Frieder, Jun Wu, and Omid C. Farokhzad. “DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy.” Angewandte Chemie International Edition 51, no. 47 (November 19, 2012): 11853-11857. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Version
Final published version
Abstract
Targeted cancer therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (see picture; PEG=polyethylene glycol). This DNA-based platform shows the ability of releasing therapeutics upon near-infrared irradiation, and remarkable targeted thermo- and chemotherapeutic efficacy in vitro and in vivo.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
MIT-Harvard Center for Cancer Nanotechnology Excellence
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1002/anie.201204018
