Replication fork instability and the consequences of fork collisions from rereplication
Name
Alexander-2016-Replication fork instability an.pdf
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561.66 KB
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Checksum (MD5)
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Author(s)
Orr-Weaver, Terry
Alexander, Jessica Lynne
Date Issued
October 2016
Journal
Genes & Development
Publisher
Cold Spring Harbor Laboratory Press
Citation
Alexander, Jessica L., and Terry L. Orr-Weaver. “Replication Fork Instability and the Consequences of Fork Collisions from Rereplication.” Genes & Development 30, no. 20 (October 15, 2016): 2241–2252.
Version
Final published version
Abstract
Replication forks encounter obstacles that must be repaired or bypassed to complete chromosome duplication before cell division. Proteomic analysis of replication forks suggests that the checkpoint and repair machinery travels with unperturbed forks, implying that they are poised to respond to stalling and collapse. However, impaired fork progression still generates aberrations, including repeat copy number instability and chromosome rearrangements. Deregulated origin firing also causes fork instability if a newer fork collides with an older one, generating double-strand breaks (DSBs) and partially rereplicated DNA. Current evidence suggests that multiple mechanisms are used to repair rereplication damage, yet these can have deleterious consequences for genome integrity.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution 4.0 International License
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DOI of Published Version
https://doi.org/10.1101/gad.288142.116
