Broken Detailed Balance of Filament Dynamics in Active Networks
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PhysRevLett.116.248301.pdf
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Author(s)
Gladrow, J.
MacKintosh, F. C.
Schmidt, C. F.
Broedersz, C. P.
Fakhri, Nikta
Date Issued
June 2016
Journal
Physical Review Letters
Publisher
American Physical Society
Citation
Gladrow, J.; Fakhri, N.; MacKintosh, F. C.; Schmidt, C. F. and Broedersz, C. P. "Broken Detailed Balance of Filament Dynamics in Active Networks." Physical Review Letters 116, 248301 (June 2016): 1-6 © 2016 American Physical Society
Version
Final published version
Abstract
Myosin motor proteins drive vigorous steady-state fluctuations in the actin cytoskeleton of cells. Endogenous embedded semiflexible filaments such as microtubules, or added filaments such as single-walled carbon nanotubes are used as novel tools to noninvasively track equilibrium and nonequilibrium fluctuations in such biopolymer networks. Here, we analytically calculate shape fluctuations of semiflexible probe filaments in a viscoelastic environment, driven out of equilibrium by motor activity. Transverse bending fluctuations of the probe filaments can be decomposed into dynamic normal modes. We find that these modes no longer evolve independently under nonequilibrium driving. This effective mode coupling results in nonzero circulatory currents in a conformational phase space, reflecting a violation of detailed balance. We present predictions for the characteristic frequencies associated with these currents and investigate how the temporal signatures of motor activity determine mode correlations, which we find to be consistent with recent experiments on microtubules embedded in cytoskeletal networks.
MIT Department
Massachusetts Institute of Technology. Department of Physics
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DOI of Published Version
https://doi.org/10.1103/PhysRevLett.116.248301
