Integration of heterogeneous expression data sets extends the role of the retinol pathway in diabetes and insulin resistance
Name
Park-2009-Integration of heterogeneous expression data.pdf
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554.2 KB
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Checksum (MD5)
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Author(s)
Park, Peter J.
Kong, Sek Won
Tebaldi, Toma
Lai, Weil R.
Kasif, Simon
Kohane, Isaac
Date Issued
September 2009
Journal
Bioinformatics
Publisher
Oxford University Press
Citation
Park, P. J. et al. “Integration of Heterogeneous Expression Data Sets Extends the Role of the Retinol Pathway in Diabetes and Insulin Resistance.” Bioinformatics 25.23 (2009): 3121–3127. Web.
Version
Final published version
Abstract
Motivation: Type 2 diabetes is a chronic metabolic disease that involves both environmental and genetic factors. To understand the genetics of type 2 diabetes and insulin resistance, the DIabetes Genome Anatomy Project (DGAP) was launched to profile gene expression in a variety of related animal models and human subjects. We asked whether these heterogeneous models can be integrated to provide consistent and robust biological insights into the biology of insulin resistance.
Results: We perform integrative analysis of the 16 DGAP data sets that span multiple tissues, conditions, array types, laboratories, species, genetic backgrounds and study designs. For each data set, we identify differentially expressed genes compared with control. Then, for the combined data, we rank genes according to the frequency with which they were found to be statistically significant across data sets. This analysis reveals RetSat as a widely shared component of mechanisms involved in insulin resistance and sensitivity and adds to the growing importance of the retinol pathway in diabetes, adipogenesis and insulin resistance. Top candidates obtained from our analysis have been confirmed in recent laboratory studies.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Creative Commons Attribution Non-Commercial
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1093/bioinformatics/btp559
