Biochemical Underpinnings of Immune Cell Metabolic Phenotypes
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nihms872111.pdf
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747.11 KB
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Author(s)
Olenchock, Benjamin A.
Rathmell, Jeffrey C.
Vander Heiden, Matthew G.
Date Issued
May 2017
Journal
Immunity
Publisher
Elsevier BV
Citation
Olenchock, Benjamin A. et al. “Biochemical Underpinnings of Immune Cell Metabolic Phenotypes.” Immunity 46, 5 (May 2017): 703–713 © 2017 Elsevier Inc
Version
Author's final manuscript
Abstract
The metabolism of immune cells affects their function and influences host immunity. This review explores how immune cell metabolic phenotypes reflect biochemical dependencies and highlights evidence that both the metabolic state of immune cells and nutrient availability can alter immune responses. The central importance of oxygen, energetics, and redox homeostasis in immune cell metabolism, and how these factors are reflected in different metabolic phenotypes, is also discussed. Linking immune cell metabolic phenotype to effector functions is important to understand how altering metabolism can impact the way in which immune cells meet their metabolic demands and affect the immune response in various disease contexts.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.IMMUNI.2017.04.013
