Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications
Name
nihms-1513142.pdf
Description
Accepted version
Size
1.52 MB
Format
Adobe PDF
Checksum (MD5)
0189e02587d375e18fc9cb1c584a6adb
Author(s)
Peng, Berney
Almeqdadi, Mohammad
Roper, Jatin
Yilmaz, Omer
Sokolov, Igor
Date Issued
March 2019
Journal
Materials today
Publisher
Elsevier BV
Citation
Peng, Berney et al. “Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications.” Materials today 23 (2019): 16-25 © 2019 The Author(s)
Version
Author's final manuscript
Abstract
Cellulose acetate (CA), viscose, or artificial silk are biocompatible human-benign derivatives of cellulose, one of the most abundant biopolymers on earth. While various optical materials have been developed from CA, optical CA nanomaterials are nonexistent. Here we report on the assembly of a new family of extremely bright fluorescent CA nanoparticles (CA-dots), which are fully suitable for in vivo imaging/targeting applications. CA-dots can encapsulate a variety of molecular fluorophores. Using various commercially available fluorophores, we demonstrate that the fluorescence of CA-dots can be tuned within the entire UV–VIS-NIR spectrum. We also demonstrate excellent specific targeting of tumors in vivo, when injected in zebrafish (xenograft model of human cervical epithelial cancer), and unusually strong exvivo topical labeling of colon cancer in mice utilizing CA folate-functionalized nanoparticles.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.mattod.2018.11.001
