Computational model of cardiovascular response to centrifugation and lower body cycling exercise
Name
japplphysiol.00314.2019.pdf
Size
2.25 MB
Format
Adobe PDF
Checksum (MD5)
f18fce8be0c0692e604eb3750bcc16b8
Author(s)
Diaz-Artiles, Ana
Heldt, Thomas
Young, Laurence Retman
Date Issued
November 2019
Journal
Journal of Applied Physiology
Publisher
American Physiological Society
Citation
Diaz-Artiles, Ana et al. "Computational model of cardiovascular response to centrifugation and lower body cycling exercise." Journal of Applied Physiology 127, 5 (November 2019): 1453-1468 © 2019 the American Physiological Society
Version
Author's final manuscript
Abstract
Short-radius centrifugation combined with exercise has been suggested as a potential countermeasure against spaceflight deconditioning. Both the long-term and acute physiological responses to such a combination are incompletely understood. We developed and validated a computational model to study the acute cardiovascular response to centrifugation combined with lower body ergometer exercise. The model consisted of 21 compartments, including the upper body, renal, splanchnic, and leg circulation, as well as a four-chamber heart and pulmonary circulation. It also included the effects of gravity gradient and ergometer exercise. Centrifugation and exercise profiles were simulated and compared with experimental data gathered on 12 subjects exposed to a range of gravitational levels (1 and 1.4G measured at the feet) and workload intensities (25–100 W). The model was capable of reproducing cardiovascular changes (within ± 1 SD from the group-averaged behavior) due to both centrifugation and exercise, including dynamic responses during transitions between the different phases of the protocol. The model was then used to simulate the hemodynamic response of hypovolemic subjects (blood volume reduced by 5–15%) subjected to similar gravitational stress and exercise profiles, providing insights into the physiological responses of experimental conditions not tested before. Hypovolemic results are in agreement with the limited available data and the expected responses based on physiological principles, although additional experimental data are warranted to further validate our predictions, especially during the exercise phases. The model captures the cardiovascular response for a range of centrifugation and exercise profiles, and it shows promise in simulating additional conditions where data collection is difficult, expensive, or infeasible.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Aeronautics and Astronautics
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1152/japplphysiol.00314.2019
