Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management
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ijms-25-03811-v2.pdf
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1.99 MB
Format
Adobe PDF
Checksum (MD5)
d484164e1f2c5227f696c9dfa6fd19d2
Author(s)
Viana Cabral, Fernanda
Quilez Alburquerque, Jose
Roberts, Harrison James
Hasan, Tayyaba
Date Issued
March 29, 2024
Journal
International Journal of Molecular Sciecnes
Publisher
MDPI AG
Citation
Viana Cabral F, Quilez Alburquerque J, Roberts HJ, Hasan T. Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management. International Journal of Molecular Sciences. 2024; 25(7):3811.
Version
Final published version
Abstract
The persistent failure of standard chemotherapy underscores the urgent need for innovative and targeted approaches in cancer treatment. Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility to subsequent therapies. This review explores the principles of PDT and discusses the concept of photodynamic priming (PDP), which augments the effectiveness of treatments like chemotherapy. Furthermore, the integration of nanotechnology for precise drug delivery at the right time and location and PDT optimization are examined. Ultimately, this study highlights the potential and limitations of PDT and PDP in cancer treatment paradigms, offering insights into future clinical applications.
Subjects
Inorganic Chemistry
Organic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Catalysis
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3390/ijms25073811
