Pd-Catalyzed Conversion of Aryl Chlorides, Triflates, and Nonaflates to Nitroaromatics
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Buchwald_Pd-catalyzed conversion.pdf
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Author(s)
Fors, Brett P.
Buchwald, Stephen Leffler
Date Issued
August 2009
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Fors, Brett P., and Stephen L. Buchwald. “Pd-Catalyzed Conversion of Aryl Chlorides, Triflates, and Nonaflates to Nitroaromatics.” Journal of the American Chemical Society 131, no. 36 (September 16, 2009): 12898-12899.
Version
Author's final manuscript
Abstract
An efficient Pd catalyst for the transformation of aryl chlorides, triflates, and nonaflates to nitroaromatics has been developed. This reaction proceeds under weakly basic conditions and displays a broad scope and excellent functional group compatibility. Moreover, this method allows for the synthesis of aromatic nitro compounds that cannot be accessed efficiently via other nitration protocols. Mechanistic insight into the transmetalation step of the catalytic process is also reported.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ja905768k
