On-chip nanoplasmonic biosensors with actively controlled nanofluidic surface delivery
Name
Yanik-2010-On-chip nanoplasmonic biosensors with actively controlled nanofluidic surface delivery.pdf
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1.46 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Yanik, Ahmet Ali
Huang, Min
Artar, Alp
Chang, Tsung-Yao
Altug, Hatice
Date Issued
August 2010
Journal
Proceedings of SPIE--the International Society for Optical Engineering; v.7757
Publisher
SPIE
Citation
Yanik, Ahmet Ali et al. “On-chip Nanoplasmonic Biosensors with Actively Controlled Nanofluidic Surface Delivery.” Proceedings of SPIE--the International Society for Optical Engineering; v.7757 (2010). 775735–775735–6. ©2010 SPIE
Version
Final published version
Abstract
Performances of surface biosensors are often controlled by the analyte delivery rate to the sensing surface instead of sensors intrinsic detection capabilities. In a microfluidic channel, analyte transports diffusively to the biosensor surface severely limiting its performance. At low concentrations, this limitation, commonly known as mass transport problem, causes impractically long detection times extending from days to months. In this proceeding, we propose and demonstrate a hybrid biosensing platform merging nanoplasmonics and nanofluidics. Unlike conventional approaches where the analytes simply stream pass over the sensing surface, our platform enables targeted delivery of analytes to the sensing surface. Our detection platform is based on extraordinary light transmission effect (EOT) in suspended plasmonic nanohole arrays. The subwavelength size nanoholes here act as nanofluidic channels connecting the microfluidic chambers on both sides of the sensors. In order to materialize our detection platform, we also introduce a novel multilayered micro/nanofluidics scheme allowing three dimensional control of the fluidic flow. Using our platform, we show 14-fold improvement in mass transport rate constant appearing in the exponential term. To fabricate these biosensors, we also introduce a lift-off free plasmonic device fabrication technique based on positive resist electron beam lithography. Simplicity of this fabrication technique allows us to fabricate nanostructures with ease, high yield/reproducibility and minimal surface roughness. As a result, we achieve higher refractive index sensitivities. This fabrication technique can find wide range of applications in nanoplasmonics field by eliminating the need for operationally slow and expensive focused ion beam lithography.
MIT Department
Massachusetts Institute of Technology. Research Laboratory of Electronics
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1117/12.860815
