Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties
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Anderson_Injectable self-healing.pdf
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Author(s)
Yesilyurt, Volkan
Webber, Matthew
Appel, Eric
Godwin, Colin
Langer, Robert S
Anderson, Daniel Griffith
Date Issued
November 2015
Journal
Advanced Materials
Publisher
Wiley Blackwell
Citation
Yesilyurt, Volkan et al. “Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties.” Advanced Materials 28.1 (2016): 86–91.
Version
Original manuscript
Abstract
Dynamically restructuring pH-responsive hydrogels are synthesized, employing dynamic covalent chemistry between phenylboronic acid and cis-diol modified poly(ethylene glycol) macromonomers. These gels display shear-thinning behavior, followed by a rapid structural recovery (self-healing). Size-dependent in vitro controlled and glucose-responsive release of proteins from the hydrogel network, as well as the biocompatibility of the gels, are evaluated both in vitro and in vivo.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/adma.201502902
