Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein
Name
Heimer-2014-Evaluating the sensitivity.pdf
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705.68 KB
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Author(s)
Shatova, Tatyana A.
Lee, Jungkyu K.
Kaastrup, Kaja
Heimer, Brandon Walter
Sikes, Hadley
Date Issued
April 2014
Journal
The Analyst
Publisher
Royal Society of Chemistry
Citation
Heimer, Brandon W., Tatyana A. Shatova, Jungkyu K. Lee, Kaja Kaastrup, and Hadley D. Sikes. “Evaluating the Sensitivity of Hybridization-Based Epigenotyping Using a Methyl Binding Domain Protein.” The Analyst 139, no. 15 (2014): 3695–3701. © 2015 Royal Society of Chemistry
Version
Final published version
Abstract
Hypermethylation of CpG islands in gene promoter regions has been shown to be a predictive biomarker for certain diseases. Most current methods for methylation profiling are not well-suited for clinical analysis. Here, we report the development of an inexpensive device and an epigenotyping assay with a format conducive to multiplexed analysis.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1039/c4an00667d
