Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates
Name
nihms811123.pdf
Description
Accepted version
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689.48 KB
Format
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Checksum (MD5)
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Author(s)
Shaw-Saliba, Kathryn
Clarke, David
Santos, Jorge M
Menezes, Maria José
Lim, Caeul
Mascarenhas, Anjali
Chery, Laura
Gomes, Edwin
March, Sandra
Bhatia, Sangeeta N
Date Issued
2016
Journal
International Journal for Parasitology
Publisher
Elsevier BV
Citation
Shaw-Saliba, K., et al. "Infection of Laboratory Colonies of Anopheles Mosquitoes with Plasmodium Vivax from Cryopreserved Clinical Isolates." Int J Parasitol (2016).
Version
Author's final manuscript
Abstract
© 2016 Australian Society for Parasitology Plasmodium vivax is the most geographically widespread malaria parasite. Unique features of transmission biology complicate P. vivax control. Interventions targeting transmission are required for malaria eradication. In the absence of an in vitro culture, transmission studies rely on live isolates from non-human primates or endemic regions. Here, we demonstrate P. vivax gametocytes from both India and Brazil are stable during cryopreservation. Importantly, cryopreserved gametocytes from Brazil were capable of infecting three anopheline mosquito species in feedings done in the United States. These findings create new opportunities for transmission studies in diverse locales.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/J.IJPARA.2016.06.003
