Metalloenzyme-like Catalyzed Isomerizations of Sugars by Lewis Acid Zeolites
Name
Roman-2012-Metalloenzyme-like Catalyzed Isomerizations of Sugars.pdf
Size
978.42 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Bermejo-Deval, Ricardo
Assary, Rajeev S.
Nikolla, Eranda
Moliner, Manuel
Roman-Leshkov, Yuriy
Hwang, Son-Jong
Palsdotter, Arna
Silverman, Dorothy
Lobo, Raul F.
Curtiss, Larry A.
Date Issued
June 2012
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences (U.S.)
Citation
Bermejo-Deval, R. et al. “Metalloenzyme-like Catalyzed Isomerizations of Sugars by Lewis Acid Zeolites.” Proceedings of the National Academy of Sciences 109.25 (2012): 9727–9732. Web. © 2012 National Academy of Sciences.
Version
Final published version
Abstract
Isomerization of sugars is used in a variety of industrially relevant processes and in glycolysis. Here, we show that hydrophobic zeolite beta with framework tin or titanium Lewis acid centers isomerizes sugars, e.g., glucose, via reaction pathways that are analogous to those of metalloenzymes. Specifically, experimental and theoretical investigations reveal that glucose partitions into the zeolite in the pyranose form, ring opens to the acyclic form in the presence of the Lewis acid center, isomerizes into the acyclic form of fructose, and finally ring closes to yield the furanose product. The zeolite catalysts provide processing advantages over metalloenzymes such as an ability to work at higher temperatures and in acidic conditions that allow for the isomerization reaction to be coupled with other important conversions.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1206708109
