E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6
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mbc.e21-01-0039.pdf
Description
Published version
Size
4.15 MB
Format
Adobe PDF
Checksum (MD5)
594700da35abd8ddd896a7b1e1d99d98
Author(s)
Hazan, Renin
Mori, Munemasa
Danielian, Paul S
Guen, Vincent J
Rubin, Seth M
Cardoso, Wellington V
Lees, Jacqueline A
Date Issued
2021
Journal
Molecular Biology of the Cell
Publisher
American Society for Cell Biology (ASCB)
Citation
Hazan, Renin, Mori, Munemasa, Danielian, Paul S, Guen, Vincent J, Rubin, Seth M et al. 2021. "E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6." Molecular Biology of the Cell, 32 (20).
Version
Final published version
Abstract
Multiciliogenesis requires both nuclear and cytoplasmic functions of the E2F4 transcription factor. Here we identify a domain in E2F4 that interacts with two key components of the cytoplasmic centriole replication machinery, Deup1 and SAS6, and is sufficient to mediate E2F4’s cytoplasmic role in multiciliogenesis.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
10.1091/MBC.E21-01-0039
