MicroRNA Control of TGF-β Signaling
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ijms-19-01901.pdf
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793.42 KB
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Adobe PDF
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b2966e06709383c6d12305040f1d90a2
Author(s)
Suzuki, Hiroshi
Date Issued
June 2018
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Citation
Suzuki, Hiroshi. "MicroRNA Control of TGF-β Signaling." International Journal of Molecular Sciences 19, 7 (June 2018): 1901 © 2018 The Author
Version
Final published version
Abstract
Transcriptional and post-transcriptional regulation shapes the transcriptome and proteome changes induced by various cellular signaling cascades. MicroRNAs (miRNAs) are small regulatory RNAs that are approximately 22 nucleotides long, which direct the post-transcriptional regulation of diverse target genes and control cell states. Transforming growth factor (TGF)-β; family is a multifunctional cytokine family, which plays many regulatory roles in the development and pathogenesis of diverse diseases, including fibrotic disease, cardiovascular disease and cancer. Previous studies have shown that the TGF-β; pathway includes the miRNA pathway as an important component of its downstream signaling cascades. Multiple studies of epithelial–mesenchymal transition (EMT)-related miRNAs have highlighted that miRNAs constitute the intrinsic bistable molecular switches of cell states by forming double negative feedback loops with EMT-inducing transcription factors. This may be important for understanding the reversibility of EMT at the single-cell level, the presence of distinct EMT transition states and the intra- and inter-tumor heterogeneity of cancer cell phenotypes. In the present review, I summarize the connection between TGF-β; signaling and the miRNA pathway, placing particular emphasis on the regulation of miRNA expression by TGF-β; signaling, the modulation of TGF-β; signaling by miRNAs, the miRNA-mediated modulation of EMT and endothelial–mesenchymal transition as well as the crosstalk between miRNA and TGF-β; pathways in the tumor microenvironment.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.3390/ijms19071901
